A BAYESIAN APPROACH TO TIME-VARYING LATENT STRENGTHS IN PAIRWISE COMPARISONS.



What Drives the Diversification of Eyespots in Morpho Butterflies? Disentangling Developmental and Selective Constraints From Neutral Evolution

Eyespots are wing color pattern elements repeatedly observed in many butterflies, whose developmental genetics has been extensively documented.Nevertheless, the evolutionary forces shaping their diversification across species still remain largely unknown.Here we investigate the evolution of eyespots in Wire Crimper the 30 species of the neotropical

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Resistance to anti-EGFR therapies in metastatic colorectal cancer: underlying mechanisms and reversal strategies

Abstract Cetuximab and panitumumab are monoclonal antibodies (mAbs) against epidermal growth factor receptor (EGFR) that are effective agents for metastatic colorectal cancer (mCRC).Cetuximab can prolong survival by 8.2 months in RAS wild-type (WT) mCRC patients.Unfortunately, resistance to targeted therapy impairs clinical use and efficiency.The m

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